Polymorphisms in the endothelial nitric oxide synthase gene and bone density/ultrasound and geometry in humans.

@article{Cho2008PolymorphismsIT,
  title={Polymorphisms in the endothelial nitric oxide synthase gene and bone density/ultrasound and geometry in humans.},
  author={Kelly Cho and Serkalem Demissie and Jos{\'e}e Dupuis and L. Adrienne Cupples and Sekar Kathiresan and Thomas J. Beck and David Karasik and Douglas P Kiel},
  journal={Bone},
  year={2008},
  volume={42 1},
  pages={53-60}
}
Nitric oxide (NO), produced by endothelial cells, is a signaling molecule synthesized from l-arginine by nitric oxide synthases (NOS). NO is known to reduce the ratio of receptor activator of nuclear factor KappaB (RANKL)/osteoprotegerin (OPG), leading to decreased osteoclastogenesis and a reduction in bone resorption. Endothelial nitric oxide synthase (eNOS or NOS3) is the predominant constitutive isoform of nitric NOS within bone. Recently, a NOS3 polymorphism, Glu298Asp, previously… CONTINUE READING