Polymorphisms in the XRCC1 gene modify survival of bladder cancer patients treated with chemotherapy.

@article{Sacerdote2013PolymorphismsIT,
  title={Polymorphisms in the XRCC1 gene modify survival of bladder cancer patients treated with chemotherapy.},
  author={Carlotta Sacerdote and Simonetta Guarrera and Fulvio Ricceri and Barbara Pardini and Silvia Polidoro and Alessandra Allione and Rossana Critelli and Alessia Russo and Angeline S. Andrew and Yuanqing Ye and X ianchao Wu and Lambertus A. L. M. Kiemeney and Andrea Bosio and Giovanni Casetta and Giuseppina Cucchiarale and Paolo Destefanis and Paulo Gontero and Luigi Rolle and Andrea Zitella and Dario Fontana and Paolo Vineis and Giuseppe Matullo},
  journal={International journal of cancer},
  year={2013},
  volume={133 8},
  pages={2004-9}
}
Survival of bladder cancer patients depends on several factors including disease stage and grade at diagnosis, age, health status of the patient and the applied treatment. Several studies investigated the role of DNA repair genetic variants in cancer susceptibility, but only few studies investigated their role in survival and response to chemotherapy for bladder cancer. We genotyped 28 single nucleotide polymorphisms (SNP) in DNA repair genes in 456 bladder cancer patients, reconstructed… CONTINUE READING
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