Polymorphisms in the SAA1 gene are associated with ankle-to-brachial index in Han Chinese healthy subjects

@article{Xie2011PolymorphismsIT,
  title={Polymorphisms in the SAA1 gene are associated with ankle-to-brachial index in Han Chinese healthy subjects},
  author={Xiang Xie and Y. Ma and Yining Yang and Z. Fu and Xiao-Mei Li and Y. Zheng and Ding Huang and Xiang Ma and Bang-dang Chen and F. Liu},
  journal={Blood Pressure},
  year={2011},
  volume={20},
  pages={232 - 238}
}
Abstract Objective. Recent study suggested that the genetic polymorphisms of serum amyloid A protein (SAA) were linked to cardiovascular disease (CVD). However, the relationship between genetic polymorphisms of SAA and ankle-to-brachial index (ABI) in healthy subjects has not been studied. We investigated the role of the SAA1 gene polymorphisms with ABI. Methods and results. All participants were selected from a cohort of healthy subjects participating in the Cardiovascular Risk Survey (CRS… Expand
Serum Uric Acid Levels Are Associated with Polymorphism in the SAA1 Gene in Chinese Subjects
TLDR
The rs122 18 SNP in the SAA1 gene was associated with SUA levels in Chinese subjects, indicating that carriers of the T allele of rs12218 have a high risk of hyperuricemia. Expand
Association of genetic polymorphisms of SAA1 (rs12218) with myocardial infarction in a Chinese population.
TLDR
It is concluded that genetic polymorphisms of SAA1 may be a genetic marker of MI in the Chinese population. Expand
SAA1 genetic polymorphisms are associated with plasma glucose concentration in non-diabetic subjects
TLDR
The genetic polymorphisms of SAA1 were associated with plasma glucose levels in non-diabetic subjects and these associations were not found in rs7131332 and rs11603089 before and after adjustment of key co-variants. Expand
Rs12218 In SAA1 gene was associated with serum lipid levels
TLDR
The results indicated that the rs12218 in the SAA1 gene was associated with lipid levels in a Chinese population. Expand
Associations of genetic polymorphisms of SAA1 with cerebral infarction
TLDR
Genetic polymorphism of SAA1 may be a genetic maker of cerebral infarction in Chinese and after adjustment of confounding factors such as sex, age, smoking, drinking, hypertension, diabetes, and lipids profile, the difference remained significant in rs12218. Expand
Genetic variation in Tanis was associated with elevating plasma triglyceride level in Chinese nondiabetic subjects
TLDR
The results indicated that the rs12910524 in the Tanis gene was associated with triglyceride concentrations in subjects without diabetes in China. Expand
Association of genetic polymorphisms of SelS with Type 2 diabetes in a Chinese population
TLDR
It is suggested that genetic polymorphisms of SelS were associated with T2DM in a Chinese population in a case–control study. Expand
Genetic polymorphisms of serum amyloid A1 and coronary artery disease risk.
TLDR
A total of four single nucleotide polymorphisms of the SAA gene were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in two independent case-control studies and found that the rs12218 CC genotype was more frequent among the CAD patients than among the controls. Expand
Association of KCNE1 genetic polymorphisms with atrial fibrillation in a Chinese Han population.
TLDR
The genetic polymorphism of KCNE1 was associated with increased risk of AF in a Chinese Han population and was found to be associated with left atrial diameter and left ventricular end diastolic diameter in AF patients. Expand
Associations of SAA1 gene polymorphism with Lipid lelvels and osteoporosis in Chinese women
TLDR
Both osteoporosis and lipids levels are associated with the TT genotype of rs12218 in the human SAA1 gene, which is found to be associated with plasma TG, HDL-C, LDL- C, and BMD levels in osteopOrosis patients. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 47 REFERENCES
Polymorphisms in the SAA1/2 Gene Are Associated with Carotid Intima Media Thickness in Healthy Han Chinese Subjects: The Cardiovascular Risk Survey
TLDR
Both rs12218 of the SAA1 gene and rs2468844 of SAA2 gene are associated with carotid IMT in healthy Han Chinese subjects. Expand
Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects.
TLDR
Variation within the ADIPOQ gene promoter is directly associated with carotid IMT in healthy subjects and is independent of circulating adiponectin levels. Expand
Haplotype Analysis of the CYP8A1 Gene Associated With Myocardial Infarction
  • Xiang Xie, Y. Ma, +5 authors Fen Liu
  • Medicine
  • Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
  • 2009
TLDR
The present results indicate that MI is associated with the CC genotype of rs5629 in the human CYP8A1 gene, and the A-C-T haplotype appears to be a useful genetic marker and the C-T-Thaplotype might be a protective factor of MI in Chinese people. Expand
Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study.
TLDR
Ass associations of SAA SNPs with baseline carotid artery intima-media thickness (cIMT) and risk of incident myocardial infarction, ischemic stroke, total CVD events or mortality during 14 years of follow-up are assessed. Expand
Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction
TLDR
The significantly combined effects of these two gene variants in the arachidonic acid metabolic pathway indicate that combining the effects of a modest number of genes could be a useful method to explore the association of genetic polymorphisms and polygenic inheritance disease. Expand
Lipoprotein(a), inflammation, and peripheral arterial disease in a community-based sample of older men and women (the InCHIANTI study).
TLDR
Lp(a) is an independent LL-PAD correlate in the cross-sectional evaluation, but further prospective studies in larger populations, with longer follow-up and more definite LL- PAD ranking, might be needed to establish a longitudinal association. Expand
Association between serum amyloid A proteins and coronary artery disease: evidence from two distinct arteriosclerotic processes.
TLDR
Environmentally determined elevations in SAA levels in patients with both spontaneous and transplant coronary artery disease provide further evidence for a potential pathophysiological link between inflammation, lipoprotein metabolism, and the development of atherosclerosis. Expand
Alcohol Consumption and Ankle-to-Brachial Index: Results from the Cardiovascular Risk Survey
TLDR
It is indicated that in Chinese men, alcohol consumption was associated with peripheral artery disease, and consumption of less than 60 g/d had an inverse association with peripheral atherosclerosis whereas consumption of 60g/d or more had a positive association. Expand
Serum Amyloid A as a Predictor of Coronary Artery Disease and Cardiovascular Outcome in Women: The National Heart, Lung, and Blood Institute–Sponsored Women’s Ischemia Syndrome Evaluation (WISE)
TLDR
These results are consistent with the hypothesis that systemic inflammation, manifested by high SAA or hs-CRP levels, may promote atherosclerotic plaque destabilization, in addition to exerting a possible direct effect on atherogenesis. Expand
Inflammation and Carotid Artery—Risk for Atherosclerosis Study (ICARAS)
TLDR
Evidence is supply for a close temporal correlation between inflammation and morphological features of rapidly progressive carotid atherosclerosis, which suggests that elevation or increase of the inflammatory biomarkers hs-CRP and SAA identifies the presence of active atherosclerotic disease. Expand
...
1
2
3
4
5
...