Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women

@inproceedings{Gartland2012PolymorphismsIT,
  title={Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women},
  author={Alison Gartland and Kristen K. Skarratt and Lynne J. Hocking and Claire Parsons and L Stokes and Niklas Rye J{\o}rgensen and W. D. Fraser and David M. Reid and James D. Gallagher and James S. Wiley},
  booktitle={European Journal of Human Genetics},
  year={2012}
}
The P2X7 receptor gene (P2RX7) is highly polymorphic with five previously described loss-of-function (LOF) single-nucleotide polymorphisms (SNP; c.151+1G>T, c.946G>A, c.1096C>G, c.1513A>C and c.1729T>A) and one gain-of-function SNP (c.489C>T). The purpose of this study was to determine whether the functional P2RX7 SNPs are associated with lumbar spine (LS) bone mineral density (BMD), a key determinant of vertebral fracture risk, in post-menopausal women. We genotyped 506 post-menopausal women… CONTINUE READING
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