Polymorphisms in the MLL breakpoint cluster region (BCR)

  title={Polymorphisms in the MLL breakpoint cluster region (BCR)},
  author={Deborah R. Echlin-Bell and Lydia L. Smith and Loretta Y. Li and Pamela L. Strissel and Reiner Strick and Vandana Gupta and Jhula Banerjee and R. Larson and Mary V. Relling and Susan C. Raimondi and Yasuhide Hayashi and Tomohiko Taki and Nancy J. Zeleznik-Le and Janet D. Rowley},
  journal={Human Genetics},
The MLL gene is involved in many chromosomal translocations leading to both acute myeloid and lymphoid leukemia. Some patients treated for primary malignancies with chemotherapeutic agents that inhibit DNA topoisomerase II (topo II) develop treatment-related leukemia (t-AML) caused by MLL gene rearrangement. Whether these patients are unusually susceptible to anti-topo II drugs, or whether this is a random adverse event is unknown. To discover genetic polymorphisms that may predispose patients… CONTINUE READING


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