Polymorphisms in the IL-13 and IL-4R genes are associated with the development of renal cell carcinoma.

@article{Chu2012PolymorphismsIT,
  title={Polymorphisms in the IL-13 and IL-4R genes are associated with the development of renal cell carcinoma.},
  author={Haiyan Chu and Meihua Wang and Fei Yan and D Zhong and Dongchen Shi and Li-xia Ma and Xiang Pan and Chengming Qin and C Yin and Zheng D Zhang},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2012},
  volume={23 8},
  pages={2114-21}
}
BACKGROUND Cytokines are the important modulators that bind to their relevant receptors in response to some stimuli to mediate the homeostasis. It has been suggested that the imbalance of immune system of the host might affect the generation of diseases, including cancers. PATIENTS AND METHODS We investigated the association between six functional polymorphisms of IL-4, IL-13, and IL-4R genes and susceptibility to renal cell cancer in a hospital-based study, including 620 renal cell carcinoma… CONTINUE READING
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