Polymorphisms in the ICAM gene locus are not associated with breast cancer Risk.


In a recent case-control study which examined >25,000 single nucleotide polymorphisms (SNP), the intercellular adhesion molecule (ICAM) locus was proposed as a susceptibility locus for breast and prostate cancer (1). The genes ICAM1, ICAM4 , and ICAM5 are all located within a 20 kb region of high linkage disequilibrium of chromosome 19p13.2. We examined the association of three previously implicated polymorphisms (rs5030382, K469E in ICAM1 ; rs281439, 542 bp upstream of ICAM5 ; rs1056538, and V301I in ICAM5) with breast cancer risk in a nested case control study within the Nurses’ Health Study.

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@article{Cox2006PolymorphismsIT, title={Polymorphisms in the ICAM gene locus are not associated with breast cancer Risk.}, author={David G. Cox and Susan E . Hankinson and David J. Hunter}, journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology}, year={2006}, volume={15 1}, pages={178-9} }