Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China.

@article{Shen2005PolymorphismsIT,
  title={Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China.},
  author={Min Shen and Sonja I. Berndt and Nathaniel Rothman and David M. DeMarini and Judy L. Mumford and Xingzhou He and Matthew Bonner and Linwei Tian and Meredith Yeager and Robert Welch and Stephen K Chanock and Tongzhang Zheng and Neil E. Caporaso and Qing Lan},
  journal={International journal of cancer},
  year={2005},
  volume={116 5},
  pages={768-73}
}
The lung cancer mortality rate in Xuan Wei County is among the highest in China and has been attributed to exposure to indoor smoky coal emissions that contain very high levels of polycyclic aromatic hydrocarbons (PAHs). Nucleotide excision repair (NER) plays a key role in reversing DNA damage from exposure to environmental carcinogens, such as PAHs, that form bulky DNA adducts. We studied single nucleotide polymorphisms (SNPs) and their corresponding haplotypes in 6 genes (ERCC1, ERCC2/XPD… CONTINUE READING
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