Polymorphisms in the ACE and PAI-1 genes are associated with recurrent spontaneous miscarriages.

@article{Buchholz2003PolymorphismsIT,
  title={Polymorphisms in the ACE and PAI-1 genes are associated with recurrent spontaneous miscarriages.},
  author={T. Buchholz and Peter William Lohse and Nina Rogenhofer and Elke Kosian and Rudolf Pihusch and Christian J. Thaler},
  journal={Human reproduction},
  year={2003},
  volume={18 11},
  pages={2473-7}
}
BACKGROUND Successful pregnancies require fine tuning of fibrinolytic activities in order to secure fibrin polymerization and stabilization of the placental basal plate as well as to prevent excess fibrin deposition in placental vessels and intervillous spaces. Fibrinolysis is tightly regulated by plasminogen activator inhibitor-1 (PAI-1). Endothelial PAI-1 synthesis is induced by angiotensin II, which is generated by angiotensin I-converting enzyme (ACE). METHODS We studied the ACE deletion… CONTINUE READING