Polymorphisms in regulatory regions of Cyclooxygenase-2 gene and breast cancer risk in Brazilians: a case-control study

@inproceedings{Piranda2010PolymorphismsIR,
  title={Polymorphisms in regulatory regions of Cyclooxygenase-2 gene and breast cancer risk in Brazilians: a case-control study},
  author={Diogo Nascimento Piranda and Juliana Sim{\~o}es Festa-Vasconcellos and Laura Murta Amaral and Anke Bergmann and Rosane Vianna-Jorge},
  booktitle={BMC Cancer},
  year={2010}
}
BackgroundCyclooxygenase-2 (COX-2) is up-regulated in several types of cancer, and it is hypothesized that COX-2 expression may be genetically influenced. Here, we evaluate the association between single-nucleotide polymorphisms (SNPs) in the COX-2 gene (PTGS2) and the occurrence of breast cancer among Brazilian women.MethodsThe study was conducted prospectively in two steps: First, we screened the promoter region and three fragments of the 3'-untranslated region of PTGS2 from 67 healthy… CONTINUE READING
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