Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains.

@article{Dimitrov2009PolymorphismsIM,
  title={Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains.},
  author={Lazar N. Dimitrov and Rachel B. Brem and Leonid Kruglyak and Daniel E Gottschling},
  journal={Genetics},
  year={2009},
  volume={183 1},
  pages={365-83}
}
The mitochondrial genome (mtDNA) is required for normal cellular function; inherited and somatic mutations in mtDNA lead to a variety of diseases. Saccharomyces cerevisiae has served as a model to study mtDNA integrity, in part because it can survive without mtDNA. A measure of defective mtDNA in S. cerevisiae is the formation of petite colonies. The frequency at which spontaneous petite colonies arise varies by approximately 100-fold between laboratory and natural isolate strains. To determine… CONTINUE READING

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