Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia.

@article{Ansari2009PolymorphismsIM,
  title={Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia.},
  author={Marc Ansari and G{\'e}raldine Sauty and Malgorzata Z Labuda and Vincent Gagn{\'e} and Caroline Laverdi{\`e}re and Albert Moghrabi and Daniel Sinnett and Maja Krajinovic},
  journal={Blood},
  year={2009},
  volume={114 7},
  pages={1383-6}
}
Methotrexate and 6-mercaptopurine, important components of acute lymphoblastic leukemia treatment, are substrates for multidrug resistance-associated protein MRP4. Eight single nucleotide polymorphisms were analyzed in MRP4 gene, and 4 variants were identified as tagSNPs with frequency more than or equal to 5%. They were investigated for association with treatment responses in 275 children with acute lymphoblastic leukemia. The TC genotype of the regulatory T-1393C polymorphism was associated… CONTINUE READING