Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis

@article{Potonik2004PolymorphismsIM,
  title={Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis},
  author={U Poto{\vc}nik and Ivan Ferkolj and Damjan Glava{\vc} and M. Dean},
  journal={Genes and Immunity},
  year={2004},
  volume={5},
  pages={530-539}
}
We used coding and noncoding polymorphisms evenly spaced across the ABCB1/MDR1 gene to perform association analysis in Slovenian patients with inflammatory bowel diseases and to obtain haplotype structure and patterns of linkage disequilibrium (LD) in the MDR1 gene. A disease association study was performed in 307 IBD patients, including 144 patients with ulcerative colitis (UC) and 163 patients with Crohn's disease (CD), and 355 healthy controls. Here we report an association between MDR1… CONTINUE READING
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