Polymorphisms in microRNA targets: a gold mine for molecular epidemiology.

  title={Polymorphisms in microRNA targets: a gold mine for molecular epidemiology.},
  author={Kexin Chen and Fengju Song and George A. Calin and Qingyi Wei and Xishan Hao and Wei Zhang},
  volume={29 7},
MicroRNAs are non-coding small RNAs that regulate gene expression by Watson-Crick base pairing to target messenger RNA (mRNA). They are involved in most biological and pathological processes, including tumorigenesis. The binding of microRNA to mRNA is critical for regulating the mRNA level and protein expression. However, this binding can be affected by single-nucleotide polymorphisms that can reside in the microRNA target site, which can either abolish existing binding sites or create… CONTINUE READING
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