Polymorphisms in microRNA genes as predictors of clinical outcomes in colorectal cancer patients.

@article{Pardini2015PolymorphismsIM,
  title={Polymorphisms in microRNA genes as predictors of clinical outcomes in colorectal cancer patients.},
  author={Barbara Pardini and Fabio Luiz Fernandes Rosa and Alessio Naccarati and Veronika Polakova Vymetalkova and Yuanqing Ye and Xifeng Wu and Cornelia Di Gaetano and Tomas Buchler and Jan P Novotn{\'y} and Giuseppe Matullo and Pavel Erik Vodicka},
  journal={Carcinogenesis},
  year={2015},
  volume={36 1},
  pages={82-6}
}
Colorectal cancer (CRC) is one of the most frequently diagnosed malignancies worldwide. It is routinely cured by a 5-fluorouracil (5-FU)-based chemotherapy which improves outcomes in patients. We investigated the effect of single nucleotide polymorphisms (SNPs) in two microRNA (miRNA)-encoding genes that have been previously reported as important in prognosis in patients with stage III CRC and treated with 5-FU-based chemotherapy. Two SNPs (rs4919510 in miR-608 and rs213210 in miR-219-1) were… CONTINUE READING
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