Polymorphisms in inflammatory cytokines and Fcgamma receptors in childhood chronic immune thrombocytopenic purpura: a pilot study.

@article{Foster2001PolymorphismsII,
  title={Polymorphisms in inflammatory cytokines and Fcgamma receptors in childhood chronic immune thrombocytopenic purpura: a pilot study.},
  author={Charles B. Foster and Saijuan Zhu and Hans Christian Erichsen and Thomas Lehrnbecher and Emily Hart and E Choi and Steven J. Stein and Michael Smith and Seth Steinberg and Paul A Imbach and Thomas K{\"u}hne and Stephen J. Chanock},
  journal={British journal of haematology},
  year={2001},
  volume={113 3},
  pages={596-9}
}
Inflammatory cytokines and low-affinity Fcgamma receptor (FcgammaR) polymorphisms were investigated in 37 children with chronic immune thrombocytopenic purpura (cITP) and 218 controls. Genotype analysis included common variants in the regulatory regions of cytokines, TNF, LTA, IL1RN, IL1A, IL1B, IL4, IL6 and IL10, and structural variants of the low affinity FcgammaRs, FCGR2A, FCGR3A and FCGR3B. Associations were observed for TNF (P = 0.0032), LTA (P = 0.019), FCGR3A (P = 0.038) and FCGR3B (P… CONTINUE READING