Polymorphisms in human langerin affect stability and sugar binding activity.

@article{Ward2006PolymorphismsIH,
  title={Polymorphisms in human langerin affect stability and sugar binding activity.},
  author={Eliot M Ward and Nicola S Stambach and Kurt Drickamer and Maureen E Taylor},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 22},
  pages={
          15450-6
        }
}
Langerhans cells are specialized skin dendritic cells that take up and degrade antigens for presentation to the immune system. Langerin, a cell surface C-type lectin of Langerhans cells, can be internalized and accumulates in Birbeck granules, subdomains of the endosomal recycling compartment that are specific to Langerhans cells. Langerin binds and mediates uptake and degradation of glycoconjugates containing mannose and related sugars. Analysis of the human genome has identified three single… CONTINUE READING

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