Polymorphisms in human connexin40 gene promoter are associated with increased risk of hypertension in men.

@article{Firouzi2006PolymorphismsIH,
  title={Polymorphisms in human connexin40 gene promoter are associated with increased risk of hypertension in men.},
  author={Mehran Firouzi and Bart G. J. M. Kok and Wilko Spiering and Andreas Busjahn and Connie R. Bezzina and J. M. Ruijter and Bobby P. C. Koeleman and Maria Schipper and W. Antoinette Groenewegen and Habo J. Jongsma and Peter Wilhelmus de Leeuw},
  journal={Journal of hypertension},
  year={2006},
  volume={24 2},
  pages={325-30}
}
OBJECTIVE Gap junctions, formed by connexins (Cx), are important in the regulation of vascular tone. Previously, we reported two closely linked polymorphisms (-44G --> A and +71A --> G) within regulatory regions of the gene for Cx40, a major connexin in the vascular wall and the kidney. In the present study, we examined the hypothesis that these polymorphic variants are associated with hypertension and that they interact with blood pressure in healthy individuals. METHODS Cx40 genotypes were… CONTINUE READING