Polymorphisms in genes related to the hypothalamic-pituitary-adrenal axis and antidepressant response – Systematic review

@article{Fischer2019PolymorphismsIG,
  title={Polymorphisms in genes related to the hypothalamic-pituitary-adrenal axis and antidepressant response – Systematic review},
  author={Susanne Fischer and Elena Silvia Gardini and Florence Haas and Anthony J Cleare},
  journal={Neuroscience & Biobehavioral Reviews},
  year={2019},
  volume={96},
  pages={182-196}
}
OBJECTIVE Around 50% of depressed patients do not respond to antidepressants. Evidence from familial studies suggests a genetic component to this. This study investigated whether patients with polymorphisms in genes related to the hypothalamic-pituitary-adrenal (HPA) axis were less likely to respond to antidepressants. METHOD EMBASE, MEDLINE, PsycINFO, and the Cochrane Library were searched. Inclusionary criteria were: 1) patients with depression, 2) study of HPA axis-related candidate genes… CONTINUE READING
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