Polymorphisms in genes related to folate and cobalamin metabolism and the associations with complex birth defects.

@article{Brouns2008PolymorphismsIG,
  title={Polymorphisms in genes related to folate and cobalamin metabolism and the associations with complex birth defects.},
  author={Raf Brouns and Nicolette T. C. Ursem and Jan W. Lindemans and Wim C. J. Hop and Smf Pluijm and Eric Steegers and R{\'e}gine P.M. Steegers-Theunissen},
  journal={Prenatal diagnosis},
  year={2008},
  volume={28 6},
  pages={485-93}
}
OBJECTIVE To investigate the associations between biomarkers and genetic variants involved in homocysteine metabolism and the risk of complex birth defects. METHODS Total homocysteine (tHcy), folate, cobalamin, apo-transcobalamin (apo-TC) and apo-haptocorrin (apo-HC) were measured in the amniotic fluid of 82 women who were pregnant with a child having a complex birth defect, such as neural tube defect, cleft lip and/or palate, heart defect or omphalocele, and in 110 women pregnant with a non… CONTINUE READING
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