Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue.

@article{Smith2006PolymorphismsIG,
  title={Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue.},
  author={Alicia K. Smith and Peter D White and Eric Aslakson and Ute Vollmer-Conna and Mangalathu S. Rajeevan},
  journal={Pharmacogenomics},
  year={2006},
  volume={7 3},
  pages={387-94}
}
Chronic fatigue syndrome (CFS) is characterized by persistent or relapsing fatigue that is not alleviated by rest, causes substantial reduction in activities and is accompanied by a variety of symptoms. Its unknown etiology may reflect that CFS is heterogeneous. Latent class analyses of symptoms and physiological systems were used to delineate subgroups within a population-based sample of fatigued and nonfatigued subjects [1] . This study examined whether genetic differences underlie the… CONTINUE READING