Polymorphisms in genes involved in homologous recombination repair interact to increase the risk of developing acute myeloid leukemia.

@article{Seedhouse2004PolymorphismsIG,
  title={Polymorphisms in genes involved in homologous recombination repair interact to increase the risk of developing acute myeloid leukemia.},
  author={Claire Helen Seedhouse and Rowena D Faulkner and Nadia Ashraf and Emma P Das-Gupta and Nigel H. Russell},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 8},
  pages={2675-80}
}
PURPOSE Double-strand break repair via homologous recombination is essential in maintaining genetic integrity. RAD51 and XRCC3 are involved in the repair of DNA by this pathway, and polymorphisms have been identified in both the RAD51 (RAD51-G135C) and XRCC3 (XRCC3-Thr241Met) genes. The object of this study was to examine whether these polymorphisms may modulate susceptibility to the development of acute myeloid leukemia (AML), a disease that is characterized by genetic instability… CONTINUE READING