Polymorphisms in genes involved in GH1 release and their association with breast cancer risk.

  title={Polymorphisms in genes involved in GH1 release and their association with breast cancer risk.},
  author={Kerstin Wagner and Kari Hemminki and Ewa Anna Grzybowska and Ruediger Klaes and Barbara Burwinkel and Peter Bugert and Rita Katharina Schmutzler and Barbara Wappenschmidt and Dorota Butkiewicz and Jolanta Pamula and Wioletta Pękala and Asta Foersti},
  volume={27 9},
The regulation of growth hormone 1 (GH1) and insulin-like-growth factor-1 (IGF-1) release is under the influence of three pituitary hormones [growth hormone releasing hormone (GHRH), ghrelin (GHRL) and somatostatin (SST)], which act in an autocrine/paracrine fashion in the breast. By binding to their respective receptors, they control cell proliferation, differentiation and apoptosis in a GH1/IGF-1-dependent manner. We investigated single nucleotide polymorphisms (SNPs) in the GHRH, GHRHR, GHRL… CONTINUE READING


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