Polymorphisms in folate metabolizing genes and risk for spontaneous preterm and small-for-gestational age birth.

@article{Engel2006PolymorphismsIF,
  title={Polymorphisms in folate metabolizing genes and risk for spontaneous preterm and small-for-gestational age birth.},
  author={Stephanie M. Engel and Andrew F Olshan and Anna Maria Siega-Riz and David A Savitz and Stephen J. Chanock},
  journal={American journal of obstetrics and gynecology},
  year={2006},
  volume={195 5},
  pages={
          1231.e1-11
        }
}
  • Stephanie M. Engel, Andrew F Olshan, +2 authors Stephen J. Chanock
  • Published 2006
  • Medicine
  • American journal of obstetrics and gynecology
  • OBJECTIVE Variants in the folate metabolism pathway affect the accumulation of homocysteine are modified by nutrient levels and have been linked to adverse birth outcomes. STUDY DESIGN We examined the relationship among MTHFR(677), MTHFR(1298), MTR(2756), MTRR(66), and SHMT1(1420), dietary folate intake, and preterm and small-for-gestational-age (SGA) birth in a nested case-control study of black and white women. RESULTS White carriers of SHMT1(1420)T or MTRR(66)A had an increased risk of… CONTINUE READING

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