Polymorphisms in folate metabolizing genes and risk for spontaneous preterm and small-for-gestational age birth.

@article{Engel2006PolymorphismsIF,
  title={Polymorphisms in folate metabolizing genes and risk for spontaneous preterm and small-for-gestational age birth.},
  author={S. Engel and A. Olshan and A. Siega-Riz and D. Savitz and S. Chanock},
  journal={American journal of obstetrics and gynecology},
  year={2006},
  volume={195 5},
  pages={
          1231.e1-11
        }
}
OBJECTIVE Variants in the folate metabolism pathway affect the accumulation of homocysteine are modified by nutrient levels and have been linked to adverse birth outcomes. STUDY DESIGN We examined the relationship among MTHFR(677), MTHFR(1298), MTR(2756), MTRR(66), and SHMT1(1420), dietary folate intake, and preterm and small-for-gestational-age (SGA) birth in a nested case-control study of black and white women. RESULTS White carriers of SHMT1(1420)T or MTRR(66)A had an increased risk of… Expand
The Effect of Interactions between Folic Acid Supplementation and One Carbon Metabolism Gene Variants on Small-for-Gestational-Age Births in the Screening for Pregnancy Endpoints (SCOPE) Cohort Study
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An overall pattern of FAS attenuating differences in the likelihood of SGA seen between genotype groups in FAS non-users is observed and future research should focus on how intake of other one-carbon nutrients might mediate these gene-nutrient interactions. Expand
Genetic variations of MTHFR gene and their association with preterm birth in Korean women.
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The findings suggested that the MTHFR gene 677 C/T and 1298 A/C polymorphisms might have protective effects for preterm birth in the Korean women. Expand
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The results imply that the relative concentrations of folate species may be more critical than total folate in preventing preterm birth. Expand
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MTHFR and MTRR gene mutation alleles are related to Down syndrome, and CT, TT and GG gene mutation types increase the risk of Down syndrome. Expand
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Identification of maternal MTHFR C677T mutation may play a key role for primary prevention of PTB as well as LBW and screening pregnant women of high risk in developing countries. Expand
Polymorphisms in maternal and fetal genes encoding for proteins involved in extracellular matrix metabolism alter the risk for small-for-gestational-age
  • D. V. Edwards, R. Romero, +19 authors Scott M. Williams
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2011
TLDR
The hypothesis that DNA variants can partially explain the risk of SGA in a cohort of Hispanic women is supported, and genetic variants in extracellular matrix-related genes showed significant single-locus association with SGA. Expand
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Testing the hypothesis that smoking in mothers with 5,10-MTHFR C677T or A1298C polymorphisms would be independently associated with lower birth weight among their offspring suggests that, in this population of native Japanese mother-child pairs, maternal 5, 10- MTHFRC677T polymorphism, but not the 5, ten-MthFR A 1298C variant, is independently associatedWith improvement in infant birth weight. Expand
Association between SNPs in genes involved in folate metabolism and preterm birth risk.
TLDR
None of the 12 SNP genotype distributions related to the folic acid metabolism pathway showed a significant difference between preterm and term babies, and the combined wild-type genotype MTHFD-G1958A, MTR-A2756G, MTHFR-A1298C, NFE2L2-ins1+C11108T, and RFC1-G80A may decrease the risk of preterm birth. Expand
Methylenetetrahydrofolate reductase polymorphisms at 3'-untranslated region are associated with susceptibility to preterm birth.
TLDR
RS1537515 and rs1537516 within the 3'-UTR of the MTHFR gene may be associated with susceptibility to PTB. Expand
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The maternal MTHFR 677C-->T polymorphism was a risk factor for placental abruption and the unexpected protective effect of the 1298A-->C polymorphism on very low birth weight needs further study. Expand
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TLDR
Variation at MTHFR codon 1298 (within the COOH-terminal region) may be more important for colon cancer than variation at codon 677 (NH(2)-terminal regions, and in populations where folate intake is low, wild-type MTH FR activity may increase risk for coloncancer. Expand
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