Polymorphisms in exon 13 and intron 14 of the RET protooncogene: genetic modifiers of medullary thyroid carcinoma?

@article{BaumgartnerParzer2005PolymorphismsIE,
  title={Polymorphisms in exon 13 and intron 14 of the RET protooncogene: genetic modifiers of medullary thyroid carcinoma?},
  author={Sabina M. Baumgartner-Parzer and Robert Lang and Laszlo Wagner and Georg Heinze and Bruno Niederle and Klaus Kaserer and Werner Waldh{\"a}usl and Heinrich Vierhapper},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 11},
  pages={6232-6}
}
CONTEXT Single-nucleotide polymorphisms (SNPs) of the RET protooncogene (RET) could modify disease susceptibility and clinical phenotype in patients with sporadic or familial medullary thyroid carcinoma (FMTC). OBJECTIVE/DESIGN OF THE STUDY: Because frequencies of RET SNPs have not yet been evaluated in patients with elevated serum concentrations of calcitonin (hCt), a biochemical marker for medullary thyroid carcinoma (MTC), we studied RET SNPs in patients with FMTC (n = 22), patients with… CONTINUE READING
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