Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease

@article{Gallicchio2006PolymorphismsIE,
  title={Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease},
  author={Lisa M Gallicchio and Sonja I. Berndt and Meghan A. McSorley and Craig Newschaffer and Lucy W. Thuita and Pedram Argani and Sandra C. Hoffman and Kathy J. Helzlsouer},
  journal={BMC Cancer},
  year={2006},
  volume={6},
  pages={173 - 173}
}
A cohort study was conducted to examine the role of genetic polymorphisms in three estrogen metabolizing enzymes (COMT, CYP1A1, CYP1B1) and the two estrogen receptors (ESR1, ESR2) in the progression of benign breast disease (BBD) to breast cancer. Among participants in an ongoing cohort study, 1438 Caucasian women had a breast biopsy for BBD and were successfully genotyped for at least one of the polymorphisms examined in this study. Genotypes were determined using DNA extracted from blood… CONTINUE READING
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