Polymorphisms in catechol-O-methyltransferase modify treatment effects of aspirin on risk of cardiovascular disease.

@article{Hall2014PolymorphismsIC,
  title={Polymorphisms in catechol-O-methyltransferase modify treatment effects of aspirin on risk of cardiovascular disease.},
  author={Kathryn T. Hall and Christopher P. Nelson and Roger B. Davis and Julie E. Buring and Irving Kirsch and Murray A. Mittleman and Joseph Loscalzo and Nilesh J. Samani and Paul M. Ridker and Ted J. Kaptchuk and Daniel Chasman},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2014},
  volume={34 9},
  pages={
          2160-7
        }
}
OBJECTIVE Catechol-O-methyltransferase (COMT), a key enzyme in catecholamine metabolism, is implicated in cardiovascular, sympathetic, and endocrine pathways. This study aimed to confirm preliminary association of COMT genetic variation with incident cardiovascular disease (CVD). It further aimed to evaluate whether aspirin, a commonly used CVD prevention agent, modified the potential association of COMT with incident CVD. APPROACH AND RESULTS We examined COMT polymorphism rs4680 (MAF [minor… CONTINUE READING
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