Polymorphisms in antithrombin and in tissue factor pathway inhibitor genes are associated with recurrent pregnancy loss.

@article{GuerraShinohara2012PolymorphismsIA,
  title={Polymorphisms in antithrombin and in tissue factor pathway inhibitor genes are associated with recurrent pregnancy loss.},
  author={Elvira Maria Guerra-Shinohara and Juliano Felix Bertinato and Carolina Tosin Bueno and Kelma Cordeiro da Silva and M{\'a}rio Henrique Burlacchini de Carvalho and Rossana Pulcineli Vieira Francisco and Marcelo Zugaib and Alvaro Cerda and V{\^a}nia Maris Morelli},
  journal={Thrombosis and haemostasis},
  year={2012},
  volume={108 4},
  pages={
          693-700
        }
}
Recurrent pregnancy loss (RPL) is a multifactorial condition. The effect of antithrombin (SERPINC1), protein C (PROC), thrombomodulin (THBD) and tissue factor pathway inhibitor (TFPI) single nucleotide polymorphisms (SNPs) on the risk of RPL is thus far unknown. Our objective was to determine the association of SNPs in the above mentioned genes with RPL. We included 117 non-pregnant women with three or more consecutive losses prior to 20 weeks of pregnancy without a previous history of carrying… CONTINUE READING
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