Polymorphisms in XRCC1 modify the association between polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, dietary antioxidants, and breast cancer risk.

@article{Shen2005PolymorphismsIX,
  title={Polymorphisms in XRCC1 modify the association between polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, dietary antioxidants, and breast cancer risk.},
  author={Jing Shuang Shen and Marilie Denise Gammon and Mary Beth Terry and Lianwen Wang and Qiao Li Wang and Fangfang Zhang and Susan L. Teitelbaum and Sybil M. Eng and Sharon K Sagiv and Mia M Gaudet and Alfred I. Neugut and Regina M. Santella},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2005},
  volume={14 2},
  pages={
          336-42
        }
}
The variability in DNA repair capacity of the general population may depend in part upon common variants in DNA repair genes. X-ray repair cross complementing group 1 (XRCC1) is an important DNA base excision repair gene and exhibits polymorphic variation. Using the Long Island Breast Cancer Study Project, a population-based case-control study, we evaluated the hypothesis that two common single nucleotide polymorphisms of XRCC1 (codon 194 Arg-->Trp and 399 Arg-->Gln) influence breast cancer… CONTINUE READING
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