Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection.


BACKGROUND The clinical course of HIV-1 infection is highly variable among individuals, at least in part as a result of genetic polymorphisms in the host. Toll-like receptors (TLRs) have a key role in innate immunity and mutations in the genes encoding these receptors have been associated with increased or decreased susceptibility to infections… (More)


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