Polymorphisms in Toll-like receptor 4 (TLR4) are associated with protection against leprosy

  title={Polymorphisms in Toll-like receptor 4 (TLR4) are associated with protection against leprosy},
  author={P.-Y. Bochud and Daniel Sinsimer and Alan Aderem and Mahveen Ruby Siddiqui and Paul Saunderson and Sven Britton and Isaac Abraham and Azeb Tadesse Argaw and Marta Janer and Thomas Richard Hawn and Gilla Kaplan},
  journal={European Journal of Clinical Microbiology & Infectious Diseases},
Accumulating evidence suggests that polymorphisms in Toll-like receptors (TLRs) influence the pathogenesis of mycobacterial infections, including leprosy, a disease whose manifestations depend on host immune responses. Polymorphisms in TLR2 are associated with an increased risk of reversal reaction, but not susceptibility to leprosy itself. We examined whether polymorphisms in TLR4 are associated with susceptibility to leprosy in a cohort of 441 Ethiopian leprosy patients and 197 healthy… CONTINUE READING


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