Polymorphisms in TRAIL receptor genes and risk of breast cancer in Spanish women.

@article{MartnezFerrandis2007PolymorphismsIT,
  title={Polymorphisms in TRAIL receptor genes and risk of breast cancer in Spanish women.},
  author={Jos{\'e} Ignacio Mart{\'i}nez-Ferrandis and Raquel Rodr{\'i}guez-L{\'o}pez and Roger L Milne and Emilio Gonz{\'a}lez and Elvira Cebolla and Isabel Chirivella and Pilar Zamora and Jos{\'e} Ignacio Arias and Santiago Palacios and Andr{\'e}s Cervantes and Orland Diez and Javier Ben{\'i}tez and M. Eugenia Armengod},
  journal={Cancer biomarkers : section A of Disease markers},
  year={2007},
  volume={3 2},
  pages={89-93}
}
TRAIL is a potent inducer of apoptosis in malignant but not in normal cells. TRAIL binds to the proapoptotic death receptor DR4 and DR5 as well as to the decoy receptors DcR1 and DcR2. To evaluate the involvement of TRAIL receptor genes in breast cancer, we carried out a case-control study of eight selected polymorphisms in a large sample of Spanish women. Three of the eight selected SNPs (626G/C and 1322G/A in DR4 and 2699A/G in DcR2) showed some evidence of different genotype distributions in… CONTINUE READING