Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease.

  title={Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease.},
  author={Wenjuan Xiao and Zelin Liu and Jianghai Lin and Jingbo Li and Kejing Wu and Yun Ma and Yingxue Gong and Zehuan Liu},
  volume={48 1},
Graves' disease (GD) is postulated to be caused by the combined effects of susceptibility genes and environmental triggers. Toll-like receptors (TLRs) play a role in the activation of innate and adaptive immune responses in mammalians. The aim of this study was to evaluate the potential association of polymorphisms in TLR1, TLR6 and TLR10 genes with GD in Chinese Cantonese population. Seven single nucleotide polymorphisms (i.e. rs4833095 and rs5743565 in TLR1; rs5743808 in TLR6; and rs4504265… CONTINUE READING
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