Polymorphisms in TGF-beta1 gene and the risk of lung cancer.

  title={Polymorphisms in TGF-beta1 gene and the risk of lung cancer.},
  author={H S Kang and Myung Hwa Chae and Jung Min Park and Eun Jin Kim and Jae Hyung Park and Sin Kam and Seung Ick Cha and Chang Ho Kim and R K Park and Sun Hee Park and Yong Lim Kim and In-San Kim and Tae Hoon Jung and Jae Yong Park},
  journal={Lung cancer},
  volume={52 1},
BACKGROUND Transforming growth factor-beta1 (TGF-beta1) functions as a suppressor of tumor initiation by inhibiting cellular proliferation or by promoting cellular differentiation or apoptosis in the early phase of cancer development. Variations in the DNA sequence in the TGF-beta1 gene may lead to altered TGF-beta1 production and/or activity, and so this can modulate an individual's susceptibility to lung cancer. To test this hypothesis, we investigated the association of the TGF-beta1 -509C… CONTINUE READING


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