Polymorphisms in TDG and MGMT Genes – Epidemiological and Functional Study in Lung Cancer Patients from Poland

@article{Krzeniak2004PolymorphismsIT,
  title={Polymorphisms in TDG and MGMT Genes – Epidemiological and Functional Study in Lung Cancer Patients from Poland},
  author={Małgorzata Krześniak and Dorota Butkiewicz and Arkadiusz Samojedny and M. Chorży and Marek Rusin},
  journal={Annals of Human Genetics},
  year={2004},
  volume={68}
}
Functional genetic polymorphisms of DNA repair genes are good candidates for cancer susceptibility markers. We studied two genes coding for proteins removing small DNA adducts by direct repair (MGMT), or mispaired DNA bases by base excision repair (TDG). The non‐silent polymorphisms of MGMT (84:Phe, 143:Val, 178:Arg) and TDG (199:Ser, 367:Met), and the functional MGMT enhancer polymorphism, did not show any statistically significant association with lung cancer risk in our case‐control analysis… 
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