Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors that Affect Treatment Outcomes for P. falciparum Malaria after Artemether-Lumefantrine and Artesunate-Amodiaquine

@inproceedings{Venkatesan2014PolymorphismsIP,
  title={Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors that Affect Treatment Outcomes for P. falciparum Malaria after Artemether-Lumefantrine and Artesunate-Amodiaquine},
  author={Meera Venkatesan and Nahla B. Gadalla and Kasia Stepniewska and Prabin Dahal and Christian Nsanzabana and Clarissa Moriera and Ric N Price and Andreas M{\aa}rtensson and Philip J. Rosenthal and Grant Dorsey and Colin J. Sutherland and Philippe J Guerin and Timothy M E Davis and Didier M{\'e}nard and Ishag Adam and George O. Ademowo and Cesar Arze and Frederick N. Baliraine and Nicole Berens-Riha and Anders Bj{\"o}rkman and Steffen Borrmann and Francesco Checchi and Meghna Desai and Mehul Dhorda and Abdoulaye A. Djimd{\'e} and Badria B. El-Sayed and Teferi Eshetu and Frederick Eyase and Catherine Olufunke Falade and J. F. Faucher and Gabrielle Fr{\"o}berg and Anastasia D Grivoyannis and Sally Hamour and Sandrine Houz{\'e} and Jacob J. Johnson and Erasmus Kamugisha and S. G. Kariuki and Jean Ren{\'e} Kiechel and Fred Kironde and P E Kofoed and Jacques Lebras and M. Michelle Malmberg and Leah Mwai and Billy E. Ngasala and François H Nosten and Samuel L. Nsobya and Alexis M Nzila and Mary Chiaka Oguike and Sabina Dahlstr{\"o}m Otienoburu and Bernhards Ogutu and J P Ouedraogo and Patrice Piola and Lars Rombo and Birgit Schramm and Anyir{\'e}kun Fabrice Som{\'e} and Julie Thwing and Johan Ursing and Rina P. M. Wong and Ahmed Zeynudin and Issaka Zongo and Christopher V. Plowe and Carol Hopkins Sibley},
  booktitle={The American journal of tropical medicine and hygiene},
  year={2014}
}
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance 1 (pfmdr1) genes are associated with decreased sensitivity to amodiaquine and lumefantrine, but effects of these polymorphisms on therapeutic responses to artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) have not been… CONTINUE READING
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