Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors that Affect Treatment Outcomes for P. falciparum Malaria after Artemether-Lumefantrine and Artesunate-Amodiaquine

@article{Venkatesan2014PolymorphismsIP,
  title={Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors that Affect Treatment Outcomes for P. falciparum Malaria after Artemether-Lumefantrine and Artesunate-Amodiaquine},
  author={M. Venkatesan and Nahla B. Gadalla and K. Stepniewska and Prabin Dahal and C. Nsanzabana and Clarissa Moriera and R. Price and A. M{\aa}rtensson and P. Rosenthal and G. Dorsey and C. Sutherland and P. Guerin and T. Davis and D. M{\'e}nard and I. Adam and G. Ademowo and Cesar Arze and F. N. Baliraine and N. Berens-Riha and A. Björkman and S. Borrmann and F. Checchi and M. Desai and M. Dhorda and A. Djimde and Badria B. El-Sayed and T. Eshetu and Frederick Eyase and C. Falade and J. Faucher and Gabrielle Fr{\"o}berg and Anastasia Grivoyannis and S. Hamour and S. Houz{\'e} and Jacob D. Johnson and Erasmus Kamugisha and S. Kariuki and J. Kiechel and F. Kironde and P. Kofoed and J. Lebras and M. Malmberg and L. Mwai and B. Ngasala and F. Nosten and S. Nsobya and A. Nzila and M. Oguike and S. D. Otienoburu and B. Ogutu and J. Ou{\'e}draogo and P. Piola and L. Rombo and B. Schramm and A. F. Som{\'e} and J. Thwing and J. Ursing and Rina P. M. Wong and A. Zeynudin and I. Zongo and C. Plowe and C. Sibley},
  journal={The American Journal of Tropical Medicine and Hygiene},
  year={2014},
  volume={91},
  pages={833 - 843}
}
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance 1 (pfmdr1) genes are associated with decreased sensitivity to amodiaquine and lumefantrine, but effects of these polymorphisms on therapeutic responses to artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) have not been… Expand
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The results suggest that artemisinin is likely to remain highly efficacious and that CQ sensitivity appears to be on the rise in western Kenya. Expand
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