Polymorphisms in NAT2, CYP2D6, CYP2C19 and GSTP1 and their association with prostate cancer.

@article{Wadelius1999PolymorphismsIN,
  title={Polymorphisms in NAT2, CYP2D6, CYP2C19 and GSTP1 and their association with prostate cancer.},
  author={Mia Wadelius and Judith L. Autrup and Michael J Stubbins and S. O. Andersson and Jan Erik Johansson and Claes Wadelius and C. R. Wolf and Herman Autrup and Anders Rane},
  journal={Pharmacogenetics},
  year={1999},
  volume={9 3},
  pages={333-40}
}
The development of prostate cancer is dependent on heredity, androgenic influences, and exposure to environmental agents. A high intake of dietary fat is associated with an increased risk of prostate cancer, either through influence on steroid hormone profiles or through production of carcinogenic compounds that require biotransformation by enzymes. The polymorphic glutathione S-transferase (GST), N-acetyltransferase (NAT), and cytochrome P450 (CYP) enzymes are of particular interest in… CONTINUE READING

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