Polymorphisms in MicroRNA Target Sites of Forkhead Box O Genes Are Associated with Hepatocellular Carcinoma

@inproceedings{Tan2015PolymorphismsIM,
  title={Polymorphisms in MicroRNA Target Sites of Forkhead Box O Genes Are Associated with Hepatocellular Carcinoma},
  author={Chao Tan and Shun Liu and Shengkui Tan and Xiaoyun Zeng and Hongping Yu and Anhua Li and Chunhua Bei and Xiao-qiang Qiu},
  booktitle={PloS one},
  year={2015}
}
The forkhead box O (FOXO) transcription factors play important roles in various cancer development including Hepatocellular Carcinoma (HCC). In this study we conducted a hospital-based case control study including 1049 cases (HCC patients) and 1052 controls (non-tumor patients) to examine whether single nucleotide polymorphisms (SNPs) within microRNA (miRNA) target sites of FOXO genes confer HCC susceptibility. A total of three miRNA target site SNPs in the 3' untranslated regions (UTR) of… CONTINUE READING
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