Polymorphisms in MMP-2 and TIMP-2 in Turkish patients with prostate cancer.

  title={Polymorphisms in MMP-2 and TIMP-2 in Turkish patients with prostate cancer.},
  author={K{\"u}rşat Oğuz Yaykaşli and Muhammet Ali Kayikçi and Nesibe Yamak and Hatice Soğuktaş and Selma D{\"u}zenli and Ali Osman Arslan and Ahmet Metın and Ertuğrul Kaya and {\"O}mer Faruk Hatıpoğlu},
  journal={Turkish journal of medical sciences},
  volume={44 5},
AIM Prostate cancer is the most commonly diagnosed malignancy and the second most common cause of cancer deaths in the Western male population. Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) modulate the remodeling of the extracellular matrix (ECM). The imbalance between MMPs and TIMPs may lead to an emergence of pathological processes such as cancer. In this study, the association between TIMP-2 (-418 G/C) and MMP-2 (-1306 C/T) polymorphisms and prostate cancer in the… CONTINUE READING


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