Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma.

@article{Chen2013PolymorphismsIJ,
  title={Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma.},
  author={Yingtai Chen and Qing Lan and Tongzhang Zheng and Nan Zhao and Theodore Holford and Catherine C. Lerro and Min Dai and Huang Huang and Jiaxin Liang and Shuangge Ma and Brian P. Leaderer and Peter Boyle and Stephen J. Chanock and Nathaniel Rothman and Yawei Zhang},
  journal={Leukemia research},
  year={2013},
  volume={37 9},
  pages={1120-4}
}
Impaired function of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway genes leads to immunodeficiency and various hematopoietic disorders. We evaluated the association between genetic polymorphisms (SNPs) in 12 JAK/STAT pathway genes (JAK3, STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6, SCOS1, SCOS2, SCOS3, and SCOS4) and NHL risk in a population-based case-control study of Connecticut women. We identified three SNPs in STAT3 (rs12949918 and… CONTINUE READING
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