Polymorphisms in HLA class I genes associated with both favorable prognosis of human immunodeficiency virus (HIV) type 1 infection and positive cytotoxic T-lymphocyte responses to ALVAC-HIV recombinant canarypox vaccines.

@article{Kaslow2001PolymorphismsIH,
  title={Polymorphisms in HLA class I genes associated with both favorable prognosis of human immunodeficiency virus (HIV) type 1 infection and positive cytotoxic T-lymphocyte responses to ALVAC-HIV recombinant canarypox vaccines.},
  author={Richard A. Kaslow and C. B. Rivers and Jianming Tang and Thomas John Bender and Paul A Goepfert and Raphaelle El Habib and K Weinhold and Mark Mulligan},
  journal={Journal of virology},
  year={2001},
  volume={75 18},
  pages={
          8681-9
        }
}
Carriers of certain human leukocyte antigen class I alleles show favorable prognosis of human immunodeficiency virus type 1 (HIV-1) infection, presumably due to effective CD8(+) cytotoxic T-lymphocyte responses, but close relationships between class I variants mediating such responses to natural and to vaccine HIV-1 antigen have not been established. During 6 to 30 months of administration and follow-up in trials of ALVAC-HIV recombinant canarypox vaccines, cells from 42% of 291 HIV-1-negative… CONTINUE READING
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Proceedings of the National Academy of Sciences of the United States of America • 2000
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Proceedings of the National Academy of Sciences of the United States of America • 2001