Polymorphisms in GSTT1, GSTM1, NAT1 and NAT2 genes and bladder cancer risk in men and women

@article{McGrath2006PolymorphismsIG,
  title={Polymorphisms in GSTT1, GSTM1, NAT1 and NAT2 genes and bladder cancer risk in men and women},
  author={Monica B McGrath and Dominique S. Michaud and Immaculata De Vivo},
  journal={BMC Cancer},
  year={2006},
  volume={6},
  pages={239 - 239}
}
Cigarette smoking is an established risk factor for bladder cancer. Epidemiological and biological data suggest that genetic polymorphisms in activating and detoxifying enzymes may play a role in determining an individual's susceptibility to bladder cancer in particular when in combination with specific environmental exposures such as cigarette smoking. N-acetyltransferase (NAT) enzymes, NAT1 and NAT2, are involved in the activation and detoxification of tobacco smoke constituents… CONTINUE READING
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GSTT1null genotype is a protective factor against bladder cancer

  • WJ Kim, H Kim, +4 authors T Katoh
  • Urology
  • 2002
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