Polymorphisms in FcγRIIIA (CD16) receptor expression are associated with clinical response to rituximab in Waldenstrom's macroglobulinemia.

@article{Treon2004PolymorphismsIF,
  title={Polymorphisms in Fc$\gamma$RIIIA (CD16) receptor expression are associated with clinical response to rituximab in Waldenstrom's macroglobulinemia.},
  author={Steven P P Treon and Mark Hansen and Andrew R. Branagan and Christos E. Emmanouilides and Eva Kimby and Stanley R. Frankel and Nikolaos Touroutoglou and David G. Maloney and Kenneth C. Anderson and Edward A. Fox},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2004},
  volume={22 14\_suppl},
  pages={6556}
}
  • S. TreonM. Hansen E. Fox
  • Published 15 July 2004
  • Medicine, Biology
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
6556 Background: Polymorphisms in FcγRIIIA (CD16) receptor expression modulate human IgG1 binding, and antibody dependent cell mediated cytotoxicity, and may therefore impact responses to rituximab in patients with WM. METHODS We therefore performed sequencing of all DNA coding regions for FcγRIIIA in 58 patients with Waldenstrom's macroglobulinemia (WM) treated with rituximab. Two distinct, but linked polymorphisms (FcγRIIIA-48 and -158) were commonly observed. All patients with FcγRIIIA… 
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FCGR2C genotyping by pyrosequencing reveals linkage disequilibrium with FCGR3A V158F and FCGR2A H131R polymorphisms in a Caucasian population

A strong and a weaker linkage disequilibrium associating the FCGR2C-ORF allele with the FC GR3A-158V and the FC2A-131H allele, respectively are demonstrated.

Increased natural killer cell expression of CD16, augmented binding and ADCC activity to rituximab among individuals expressing the Fc{gamma}RIIIa-158 V/V and V/F polymorphism.

Results suggest that individuals expressing at least one valine at FcgammaRIIIa-158 might, in part, have better clinical outcomes due to increased CD16 expression, rituximab binding, and ritUXimab-mediated, antibody-dependent cellular cytotoxicity (ADCC).

The 158VV Fcgamma receptor 3A genotype is associated with response to rituximab in rheumatoid arthritis: results of an Italian multicentre study

The 158VV FCGR3A genotype was associated with response to RTX in a large cohort of RA patients and may be helpful to plan RTX treatment, and May be integrated with clinical predictors.

Immunoglobulin G Fc receptor FcgammaRIIIa 158 V/F polymorphism correlates with rituximab-induced neutropenia after autologous transplantation in patients with non-Hodgkin's lymphoma.

The high affinity FcgammaRIIIa 158 V allele is associated with rituximab-induced neutropenia after autologous transplantation and is a potential tool to identify a high-risk population for developing neutropania after antibody therapy.

Flow cytometric assay for determination of FcγRIIIA-158 V/F polymorphism

Association of the FCGR3A-158F/V gene polymorphism with the response to rituximab treatment in Spanish systemic autoimmune disease patients.

Results suggest that FCGR3A-158F/V (rs396991) gene polymorphism play a role in the response to rituximab in autoimmune diseases.

The Effect of FcγRIIIA Gene Polymorphism on the Treatment of Diffuse Large B-cell Non-Hodgkin Lymphoma: A Multicenter Prospective Observational Study

While ORR was similar between the groups, the results highlight a lower OS in F/F patients compared to other allele groups of FcγRIIIA, which is similar to those of previous studies.

The Efficacy of Rituximab plus Hyper-CVAD Regimen in Mantle Cell Lymphoma Is Independent of FCγRIIIa and FCγRIIa Polymorphisms

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