Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment

  title={Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment},
  author={Elisabeth B. Binder and Daria Salyakina and Peter Lichtner and Gabriele M Wochnik and Marcus Ising and Benno Puetz and Sergi Papiol and Shaun R Seaman and Susanne Lucae and Martin A. Kohli and Thomas Nickel and Heike E. Kuenzel and Brigitte Fuchs and Matthias Majer and Andrea Pfennig and Nikola Kern and J{\"u}rgen Brunner and Sieglinde Modell and Thomas C. Baghai and Tobias Deiml and Peter Zill and Brigitta Bondy and Rainer Rupprecht and Thomas C Messer and Oliver K{\"o}hnlein and Heike Dabitz and Tanja Maria Br{\"u}ckl and Nina M{\"u}ller and Hildegard Pfister and Roselind Lieb and Jakob C. Mueller and Elin L{\~o}hmussaar and Tim Matthias Strom and Thomas Bettecken and Thomas Meitinger and M. Uhr and Theo Rein and Florian Holsboer and Bertram Muller-Myhsok},
  journal={Nature Genetics},
The stress hormone–regulating hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the causality as well as the treatment of depression. To investigate a possible association between genes regulating the HPA axis and response to antidepressants and susceptibility for depression, we genotyped single-nucleotide polymorphisms in eight of these genes in depressed individuals and matched controls. We found significant associations of response to antidepressants and the recurrence of… CONTINUE READING
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