Polymorphisms in ERCC1 and susceptibility to childhood acute lymphoblastic leukemia in a Chinese population.

@article{Wang2006PolymorphismsIE,
  title={Polymorphisms in ERCC1 and susceptibility to childhood acute lymphoblastic leukemia in a Chinese population.},
  author={Si Li Wang and Hui Zhao and Bin Zhou and Yong Li Chen and Yao Zou and Xiao Fan Zhu and Qing Shan Li and Ming Zhe Han and Ren Chi Yang and Zhong Han},
  journal={Leukemia research},
  year={2006},
  volume={30 11},
  pages={1341-5}
}
Excision repair cross-complementation group 1 (ERCC1) is important in repairing DNA damage and genomic instability, and polymorphisms in ERCC1 may play a role in human tumors. In this study, the relationship of two ERCC1 polymorphisms, 8092C>A and 19007G>A, with susceptibility to acute lymphoblastic leukemia (ALL) was investigated in 183 childhood patients. For the ERCC1 8092C>A polymorphism, individuals carrying the ERCC1 8092CC genotype had a significantly higher risk when compared with those… CONTINUE READING
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