Polymorphisms in ERCC1 and XPF Genes and Risk of Gastric Cancer in an Eastern Chinese Population

@inproceedings{He2012PolymorphismsIE,
  title={Polymorphisms in ERCC1 and XPF Genes and Risk of Gastric Cancer in an Eastern Chinese Population},
  author={Jing He and Yu Xu and Li-Xin Qiu and Jin Li and Xiaoyan Zhou and Meng-hong Sun and Jiu-cun Wang and Yajun Yang and Li Jin and Qing-yi Wei and Yanong Wang},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Inherited functional single nucleotide polymorphisms (SNPs) in DNA repair genes may alter DNA repair capacity and thus contribute to cancer risk. METHODS Three ERCC1 functional SNPs (rs2298881C>A, rs3212986C>A and rs11615G>A) and two XPF/ERCC4 functional SNPs (rs2276466C>G and rs6498486A>C) were genotyped for 1125 gastric adenocarcinoma cases and 1196 cancer-free controls by Taqman assays. Odds ratios (OR) and 95% confidence intervals (CI) were used to estimate risk associations… CONTINUE READING