Polymorphisms in E-cadherin (CDH1) result in a mis-localised cytoplasmic protein that is associated with Crohn's disease.

@article{Muise2009PolymorphismsIE,
  title={Polymorphisms in E-cadherin (CDH1) result in a mis-localised cytoplasmic protein that is associated with Crohn's disease.},
  author={Aleixo M Muise and Thomas D Walters and Wioletta K. Glowacka and Anne Marie Griffiths and B-Y Ngan and Hui Y Lan and Wei Xu and Mark S. Silverberg and Daniela Rotin},
  journal={Gut},
  year={2009},
  volume={58 8},
  pages={1121-7}
}
BACKGROUND Patients with Crohn's disease have defects in intestinal epithelial permeability that are inadequately explained by known inflammatory bowel disease (IBD) susceptibility genes. E-cadherin (CDH1) plays a vital role in maintaining the integrity of the intestinal barrier and its cellular localisation is disrupted in patients with Crohn's disease. AIM To determine if polymorphisms in the CDH1 gene are associated with Crohn's disease and to determine the function associated with these… CONTINUE READING

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