Polymorphisms in DNA damage binding protein 2 (DDB2) and susceptibility of primary lung cancer in the Chinese: a case-control study.

@article{Hu2006PolymorphismsID,
  title={Polymorphisms in DNA damage binding protein 2 (DDB2) and susceptibility of primary lung cancer in the Chinese: a case-control study.},
  author={Zhibin Hu and Minhua Shao and Jing Yuan and Liang Xu and Feng Wang and Yi Wang and Wentao Yuan and Ji Qian and Hongxia Ma and Ying Wang and Hongliang Liu and Weihong Chen and Lin Yang and Guangfu Jin and Xiang Huo and Feng Chen and Li Jin and Qingyi Wei and Wei Huang and Daru Lu and Tangchun Wu and Hongbing Shen},
  journal={Carcinogenesis},
  year={2006},
  volume={27 7},
  pages={1475-80}
}
DNA damage binding protein 2 (DDB2) is one of the major DNA repair proteins involved in the nucleotide excision repair (NER) pathway. Mutations in the DDB2 gene can cause a repair-deficiency syndrome xeroderma pigmentosum group E. Because tobacco carcinogens can cause DNA damage that is repaired by NER and suboptimal NER capacity is reported to be associated with lung cancer risk, we hypothesized that common variants in the DDB2 gene are associated with lung cancer risk. To test this hypothesis… CONTINUE READING
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