• Biology, Medicine
  • Published in
    The Journal of clinical…
    2003
  • DOI:10.1172/jci17993

Polymorphisms in Chlamydia trachomatis tryptophan synthase genes differentiate between genital and ocular isolates.

@article{Caldwell2003PolymorphismsIC,
  title={Polymorphisms in Chlamydia trachomatis tryptophan synthase genes differentiate between genital and ocular isolates.},
  author={Harlan D. Caldwell and Heidi Wood and Debbie Crane and Robin L. Bailey and Robert B. Jones and David Mabey and Ian Maclean and Zeena Mohammed and Rosanna Peeling and Christine Roshick and Julius Schachter and Anthony W Solomon and Walter E. Stamm and Robert J Suchland and Lacey D. Taylor and Sheila K West and Tom Quinn and Robert J. Belland and Grant McClarty},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={111 11},
  pages={
          1757-69
        }
}
We previously reported that laboratory reference strains of Chlamydia trachomatis differing in infection organotropism correlated with inactivating mutations in the pathogen's tryptophan synthase (trpBA) genes. Here, we have applied functional genomics to extend this work and find that the paradigm established for reference serovars also applies to clinical isolates - specifically, all ocular trachoma isolates tested have inactivating mutations in the synthase, whereas all genital isolates… CONTINUE READING

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